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Neural Correlates of the Psychedelic State as Determined by fMRI Studies with Psilocybin

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Altered States PsychedelicsDefault Mode Network

By Robin L. Carhart-Harris, David J. Nutt, et al.

Summary

First fMRI study of psilocybin in humans: decreased DMN activity and connectivity, increased global brain connectivity. DMN activity predicted subjective intensity. Introduced "entropic brain" framework.

Why It Matters

Foundational neurobiological account of how psychedelics alter consciousness — DMN disintegration as the neural correlate of ego dissolution.

Notes

This entry is a seed import from the Phase 1 Knowledge Inventory. It has not yet been manually reviewed.